Survey Asks: How Does Tadalafil Work?


 Tadalafil is used to treat subjects who experience difficulty having and maintaining an erection to orgasm.

Medical testing has shown that Cialis is effective in 60%-80% of cases when used to treat erectile dysfunction in subjects. Most failure cases are from subjects that have had some form of surgery that made getting or maintaining an erection physically impossible. Tadalafil produces results similar to Viagra, but the effects of Tadalafil last longer than Viagra. In addition, Tadalafil can be taken on an empty stomach or with a meal. When Tadalafil and Viagra were compared in a study Tadalafil allowed for more sexual frequency and that in turn raised Testosterone levels higher in the Cialis group.

How Does Tadalafil Work

Medications like Tadalafil work by inhibiting a chemical called phosphodiesterase type 5. Because of their mode of action, these drugs are commonly referred to simply as PDE5 inhibitors. When a man gets sexually excited, it triggers cells in the penis to produce nitric oxide. The increase in nitric oxide will in turn cause production of cyclic guanosine monophosphate (cGMP). The cGMP causes arteries in part of the penis to relax and allow more blood to flow through them. The increase in blood flow causes an erection. If the enzyme phosphodiesterase type 5 (PDE5) is of sufficient quantity, it will attack the cGMP and erection will not be maintained. Tadalafil and other PDE5 inhibitors reduce the amount of PDE5 available to attack cGMP. With a reduction of PDE5, most subjects are able to maintain an erection to orgasm.

How Long Do the Effects of Tadalafil Last

The effects of Tadalafil have been shown to last 24 to 36 hours in a majority of users. The effects of Viagra have been shown to last 4 to 6 hours in a majority of users. Some subjects like the fact that Tadalafil works for up to 36 hours and allows the user and his partner to relax, forget about planning intimacy and let things happen when the moment is right. 24 to 36 hours might seem ideal but some men report they switched back to Viagra because 6 hours or less was what they preferred. Taking Tadalafil does not increase sexual desire and it will not give you an erection for 36 hours. Most subjects who take Tadalafil report that for up to 36 hours after taking Cialis, an erection can be sustained when the penis was stimulated by touch. After orgasm, the penis will usually return to its pre-aroused state. Some subjects may be able to have one or more orgasms after the first but this an exception. In most cases, within 36 hours of taking 20 milligrams of cialis, you will be able to get and maintain an erection to orgasm one time. Most subjects that have had more than one orgasm from a single dose say they had the first orgasm within 60-180 minutes of taking cialis then were able to have one or more orgasms by waiting 60 minutes or longer before any more penis stimulation was attempted. This is something the user will have to experiment with to find out their own particular climax capacity.

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